NMDAR2A/B Antibody
Product Sizes
100 ug
£496.00
OAAF07581-100UG
About this Product
- SKU:
- OAAF07581
- Additional Names:
- DEE27;EIEE27;EPND;FESD;GluN2A;GluN2B;GluN2B(alt_5'UTR);Glutamate [NMDA] receptor subunit epsilon-1;glutamate [NMDA] receptor subunit epsilon-2;glutamate ionotropic receptor NMDA 2A;glutamate receptor ionotropic; NMDA 2A;glutamate receptor ionotropic; NMDA 2B;glutamate receptor subunit epsilon-2;glutamate receptor; ionotropic; N-methyl D-aspartate 2A;glutamate receptor; ionotropic; N-methyl D-aspartate 2B;hNR3;LKS;MRD6;NMDAR2A;NMDAR2B;N-methyl D-aspartate receptor subtype 2A;N-methyl D-aspartate receptor subtype 2B;N-methyl-D-aspartate receptor channel; subunit epsilon-1;N-methyl-D-aspartate receptor subunit 2A;N-methyl-D-aspartate receptor subunit 3;NR2A;NR2B;NR3.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735; PubMed:26919761; PubMed:26875626; PubMed:28105280). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kinetics than channels formed by GRIN1 and GRIN2B (PubMed:26919761; PubMed:26875626). Contributes to the slow phase of excitatory postsynaptic current; long-term synaptic potentiation; and learning (By similarity).|Component of NMDA receptor complexes that function as heterotetrameric; ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit; glycine binding to the zeta subunit; plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:8768735; PubMed:26919761; PubMed:26875626; PubMed:28126851). Sensitivity to glutamate and channel kinetics depend on the subunit composition (PubMed:8768735; PubMed:26875626). In concert with DAPK1 at extrasynaptic sites; acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them; resulting in an irreversible neuronal death. Contributes to neural pattern formation in the developing brain. Plays a role in long-term depression (LTD) of hippocampus membrane currents and in synaptic plasticity (By similarity).
- Gene Details:
- glutamate ionotropic receptor NMDA type subunit 2A|glutamate ionotropic receptor NMDA type subunit 2B
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human NMDAR2A/B around the phosphorylation site of Tyr1246/1252.
- Molecular Weight:
- 165 kDa
- Protein Details:
- Glutamate receptor ionotropic; NMDA 2A|Glutamate receptor ionotropic; NMDA 2B
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
