JIP1 Antibody
Product Sizes
100 ug
£496.00
OAAF07580-100UG
About this Product
- SKU:
- OAAF07580
- Additional Names:
- C-Jun-amino-terminal kinase-interacting protein 1;IB1;IB-1;islet-brain 1;JIP1;JIP-1;JNK MAP kinase scaffold protein 1;JNK-interacting protein 1;Mitogen-activated protein kinase 8-interacting protein 1;PRKM8 interacting protein;PRKM8IP.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Required for JNK activation in response to excitotoxic stress. Cytoplasmic MAPK8IP1 causes inhibition of JNK-regulated activity by retaining JNK in the cytoplasm and inhibiting JNK phosphorylation of c-Jun. May also participate in ApoER2-specific reelin signaling. Directly; or indirectly; regulates GLUT2 gene expression and beta-cell function. Appears to have a role in cell signaling in mature and developing nerve terminals. May function as a regulator of vesicle transport; through interactions with the JNK-signaling components and motor proteins (By similarity). Functions as an anti-apoptotic protein and whose level seems to influence the beta-cell death or survival response.
- Gene Details:
- mitogen-activated protein kinase 8 interacting protein 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human JIP1 around the phosphorylation site of Thr103.
- Molecular Weight:
- 77 kDa
- Protein Details:
- C-Jun-amino-terminal kinase-interacting protein 1
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
