FAK Antibody
Product Sizes
100 ug
£496.00
OAAF07560-100UG
About this Product
- SKU:
- OAAF07560
- Additional Names:
- FADK;FADK 1;FAK;FAK1;FAK-related non-kinase polypeptide;focal adhesion kinase 1;focal adhesion kinase-related nonkinase;FRNK;p125FAK;pp125FAK;PPP1R71;protein phosphatase 1 regulatory subunit 71;Protein-tyrosine kinase 2;PTK2 protein tyrosine kinase 2.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration; adhesion; spreading; reorganization of the actin cytoskeleton; formation and disassembly of focal adhesions and cell protrusions; cell cycle progression; cell proliferation and apoptosis. Required for early embryonic development and placenta development. Required for embryonic angiogenesis; normal cardiomyocyte migration and proliferation; and normal heart development. Regulates axon growth and neuronal cell migration; axon branching and synapse formation; required for normal development of the nervous system. Plays a role in osteogenesis and differentiation of osteoblasts. Functions in integrin signal transduction; but also in signaling downstream of numerous growth factor receptors; G-protein coupled receptors (GPCR); EPHA2; netrin receptors and LDL receptors. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues; creating binding sites for scaffold proteins; effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascade. Promotes activation of MAPK1/ERK2; MAPK3/ERK1 and the MAP kinase signaling cascade. Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs); and thereby modulates the activity of Rho family GTPases. Signaling via CAS family members mediates activation of RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus; and thereby regulates P53/TP53 activity; P53/TP53 ubiquitination and proteasomal degradation. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ACTN1; ARHGEF7; GRB7; RET and WASL. Promotes phosphorylation of PXN and STAT1; most likely PXN and STAT1 are phosphorylated by a SRC family kinase that is recruited to autophosphorylated PTK2/FAK1; rather than by PTK2/FAK1 itself. Promotes phosphorylation of BCAR1; GIT2 and SHC1; this requires both SRC and PTK2/FAK1. Promotes phosphorylation of BMX and PIK3R1. Isoform 6 (FRNK) does not contain a kinase domain and inhibits PTK2/FAK1 phosphorylation and signaling. Its enhanced expression can attenuate the nuclear accumulation of LPXN and limit its ability to enhance serum response factor (SRF)-dependent gene transcription.
- Gene Details:
- protein tyrosine kinase 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FAK around the phosphorylation site of Ser910.
- Molecular Weight:
- 119 kDa
- Protein Details:
- Focal adhesion kinase 1
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
