Retinoblastoma Antibody
Product Sizes
100 ug
£496.00
OAAF07522-100UG
About this Product
- SKU:
- OAAF07522
- Additional Names:
- exon 17 tumor GOS561 substitution mutation causes premature stop;GOS563 exon 17 substitution mutation causes premature stop;OSRC;p105-Rb;p110-RB1;pp110;PPP1R130;pRb;prepro-retinoblastoma-associated protein;protein phosphatase 1; regulatory subunit 130;RB;retinoblastoma 1;retinoblastoma suspectibility protein;retinoblastoma-associated protein.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Key regulator of entry into cell division that acts as a tumor suppressor. Promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target genes. The underphosphorylated; active form of RB1 interacts with E2F1 and represses its transcription activity; leading to cell cycle arrest. Directly involved in heterochromatin formation by maintaining overall chromatin structure and; in particular; that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1; KMT5B and KMT5C; leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Inhibits the intrinsic kinase activity of TAF1. Mediates transcriptional repression by SMARCA4/BRG1 by recruiting a histone deacetylase (HDAC) complex to the c-FOS promoter. In resting neurons; transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx; RB1 is dephosphorylated by calcineurin; which leads to release of the repressor complex (By similarity). In case of viral infections; interactions with SV40 large T antigen; HPV E7 protein or adenovirus E1A protein induce the disassembly of RB1-E2F1 complex thereby disrupting RB1's activity.
- Gene Details:
- RB transcriptional corepressor 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Retinoblastoma around the phosphorylation site of Thr821.
- Molecular Weight:
- 106 kDa
- Protein Details:
- Retinoblastoma-associated protein
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
