Breast Tumor Kinase Antibody
Product Sizes
100 ug
£496.00
OAAF07517-100UG
About this Product
- SKU:
- OAAF07517
- Additional Names:
- breast tumor kinase;BRK;protein-tyrosine kinase 6;protein-tyrosine kinase BRK;PTK6 protein tyrosine kinase 6;tyrosine-protein kinase BRK.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Non-receptor tyrosine-protein kinase implicated in the regulation of a variety of signaling pathways that control the differentiation and maintenance of normal epithelia; as well as tumor growth. Function seems to be context dependent and differ depending on cell type; as well as its intracellular localization. A number of potential nuclear and cytoplasmic substrates have been identified. These include the RNA-binding proteins: KHDRBS1/SAM68; KHDRBS2/SLM1; KHDRBS3/SLM2 and SFPQ/PSF; transcription factors: STAT3 and STAT5A/B and a variety of signaling molecules: ARHGAP35/p190RhoGAP; PXN/paxillin; BTK/ATK; STAP2/BKS. Associates also with a variety of proteins that are likely upstream of PTK6 in various signaling pathways; or for which PTK6 may play an adapter-like role. These proteins include ADAM15; EGFR; ERBB2; ERBB3 and IRS4. In normal or non-tumorigenic tissues; PTK6 promotes cellular differentiation and apoptosis. In tumors PTK6 contributes to cancer progression by sensitizing cells to mitogenic signals and enhancing proliferation; anchorage-independent survival and migration/invasion. Association with EGFR; ERBB2; ERBB3 may contribute to mammary tumor development and growth through enhancement of EGF-induced signaling via BTK/AKT and PI3 kinase. Contributes to migration and proliferation by contributing to EGF-mediated phosphorylation of ARHGAP35/p190RhoGAP; which promotes association with RASA1/p120RasGAP; inactivating RhoA while activating RAS. EGF stimulation resulted in phosphorylation of PNX/Paxillin by PTK6 and activation of RAC1 via CRK/CrKII; thereby promoting migration and invasion. PTK6 activates STAT3 and STAT5B to promote proliferation. Nuclear PTK6 may be important for regulating growth in normal epithelia; while cytoplasmic PTK6 might activate oncogenic signaling pathways.
- Gene Details:
- protein tyrosine kinase 6
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Breast Tumor Kinase around the phosphorylation site of Tyr447.
- Molecular Weight:
- 51 kDa
- Protein Details:
- Protein-tyrosine kinase 6
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
