53BP1 Antibody
Product Sizes
100 ug
£496.00
OAAF07505-100UG
About this Product
- SKU:
- OAAF07505
- Additional Names:
- 53BP1;p202;p53-binding protein 1;p53BP1;TDRD30;TP53-binding protein 1;tumor protein 53-binding protein; 1;tumor suppressor p53-binding protein 1.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Double-strand break (DSB) repair protein involved in response to DNA damage; telomere dynamics and class-switch recombination (CSR) during antibody genesis (PubMed:12364621; PubMed:22553214; PubMed:23333306; PubMed:17190600; PubMed:21144835; PubMed:28241136). Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1 (PubMed:22553214; PubMed:23727112; PubMed:23333306). In response to DSBs; phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR; leading to recruitment to DSBs sites (PubMed:28241136). Recruited to DSBs sites by recognizing and binding histone H2A monoubiquitinated at 'Lys-15' (H2AK15Ub) and histone H4 dimethylated at 'Lys-20' (H4K20me2); two histone marks that are present at DSBs sites (PubMed:23760478; PubMed:28241136; PubMed:17190600). Required for immunoglobulin class-switch recombination (CSR) during antibody genesis; a process that involves the generation of DNA DSBs (PubMed:23345425). Participates to the repair and the orientation of the broken DNA ends during CSR (By similarity). In contrast; it is not required for classic NHEJ and V(D)J recombination (By similarity). Promotes NHEJ of dysfunctional telomeres via interaction with PAXIP1 (PubMed:23727112).
- Gene Details:
- tumor protein p53 binding protein 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human 53BP1 around the phosphorylation site of Ser6.
- Molecular Weight:
- 213 kDa
- Protein Details:
- TP53-binding protein 1
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
