Aurora Kinase Antibody
Product Sizes
100 ug
£496.00
OAAF07369-100UG
About this Product
- SKU:
- OAAF07369
- Additional Names:
- AIK;ARK1;AURA;aurora 2;aurora kinase A;aurora/IPL1-like kinase;aurora/IPL1-related kinase 1;breast tumor-amplified kinase;BTAK;PPP1R47;protein phosphatase 1; regulatory subunit 47;serine/threonine protein kinase 15;Serine/threonine-protein kinase 15;serine/threonine-protein kinase 6;serine/threonine-protein kinase aurora-A;STK15;STK6;STK7.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Mitotic serine/threonine kinase that contributes to the regulation of cell cycle progression. Associates with the centrosome and the spindle microtubules during mitosis and plays a critical role in various mitotic events including the establishment of mitotic spindle; centrosome duplication; centrosome separation as well as maturation; chromosomal alignment; spindle assembly checkpoint; and cytokinesis. Required for initial activation of CDK1 at centrosomes. Phosphorylates numerous target proteins; including ARHGEF2; BORA; BRCA1; CDC25B; DLGP5; HDAC6; KIF2A; LATS2; NDEL1; PARD3; PPP1R2; PLK1; RASSF1; TACC3; p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase activity. Required for normal axon formation. Plays a role in microtubule remodeling during neurite extension. Important for microtubule formation and/or stabilization. Also acts as a key regulatory component of the p53/TP53 pathway; and particularly the checkpoint-response pathways critical for oncogenic transformation of cells; by phosphorylating and stabilizing p53/TP53. Phosphorylates its own inhibitors; the protein phosphatase type 1 (PP1) isoforms; to inhibit their activity. Necessary for proper cilia disassembly prior to mitosis.
- Gene Details:
- aurora kinase A
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Aurora Kinase around the phosphorylation site of Thr288.
- Isotype:
- IgG
- Molecular Weight:
- 45 kDa
- Protein Details:
- Aurora kinase A
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
