COT Antibody
Product Sizes
100 ug
£496.00
OAAF07328-100UG
About this Product
- SKU:
- OAAF07328
- Additional Names:
- augmented in rheumatoid arthritis 2;AURA2;Cancer Osaka thyroid oncogene;c-COT;COT;cot (cancer Osaka thyroid) oncogene;EST;ESTF;Ewing sarcoma transformant;MEKK8;mitogen-activated protein kinase kinase kinase 8;proto-oncogene c-Cot;proto-oncogene serine/threoine protein kinase;Serine/threonine-protein kinase cot;Tpl-2;TPL2;tumor progression locus 2.
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- Required for lipopolysaccharide (LPS)-induced; TLR4-mediated activation of the MAPK/ERK pathway in macrophages; thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro; activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner; leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages; and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes; activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF; but not insulin; leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity; although it is much weaker than that of the activated oncogenic variant.
- Gene Details:
- mitogen-activated protein kinase kinase kinase 8
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human COT around the phosphorylation site of Thr290.
- Molecular Weight:
- 52 kDa
- Protein Details:
- Mitogen-activated protein kinase kinase kinase 8
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
