LGR4 Antibody
Product Sizes
100 ug
£496.00
OAAF04974-100UG
About this Product
- SKU:
- OAAF04974
- Additional Names:
- BNMD17;G protein-coupled receptor 48;GPR48;G-protein coupled receptor 48;leucine-rich repeat-containing G-protein coupled receptor 4.
- Clonality:
- Polyclonal
- Extra Details:
- Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1; RSPO2; RSPO3 or RSPO4); associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors; triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors; does not activate heterotrimeric G-proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs; including liver; kidney; intestine; bone; reproductive tract and eye. May also act as a receptor for norrin (NDP); such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and proinflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids; partially through regulating the rhythmic expression of MTTP (By similarity).
- Gene Details:
- leucine rich repeat containing G protein-coupled receptor 4
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human LGR4.
- Molecular Weight:
- 104 kDa
- Protein Details:
- Leucine-rich repeat-containing G-protein coupled receptor 4
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
