CNR1 Antibody
Product Sizes
100 ug
£496.00
OAAF04868-100UG
About this Product
- SKU:
- OAAF04868
- Additional Names:
- CANN6;cannabinoid receptor 1;cannabinoid receptor 1 (brain);CB1;CB1A;CB1K5;CB1R;CB-R;central cannabinoid receptor;CNR.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- G-protein coupled receptor for endogenous cannabinoids (eCBs); including N-arachidonoylethanolamide (also called anandamide or AEA) and 2-arachidonoylglycerol (2-AG); as well as phytocannabinoids; such as delta(9)-tetrahydrocannabinol (THC) (PubMed:15620723; PubMed:27768894; PubMed:27851727). Mediates many cannabinoid-induced effects; acting; among others; on food intake; memory loss; gastrointestinal motility; catalepsy; ambulatory activity; anxiety; chronic pain. Signaling typically involves reduction in cyclic AMP (PubMed:1718258; PubMed:21895628; PubMed:27768894). In the hypothalamus; may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses; while decreases respiration at high doses. At high doses; CNR1 signal transduction involves G-protein alpha-i protein activation and subsequent inhibition of mitochondrial soluble adenylate cyclase; decrease in cyclic AMP concentration; inhibition of protein kinase A (PKA)-dependent phosphorylation of specific subunits of the mitochondrial electron transport system; including NDUFS2. In the hypothalamus; inhibits leptin-induced reactive oxygen species (ROS) formation and mediates cannabinoid-induced increase in SREBF1 and FASN gene expression. In response to cannabinoids; drives the release of orexigenic beta-endorphin; but not that of melanocyte-stimulating hormone alpha/alpha-MSH; from hypothalamic POMC neurons; hence promoting food intake. In the hippocampus; regulates cellular respiration and energy production in response to cannabinoids. Involved in cannabinoid-dependent depolarization-induced suppression of inhibition (DSI); a process in which depolarization of CA1 postsynaptic pyramidal neurons mobilizes eCBs; which retrogradely activate presynaptic CB1 receptors; transiently decreasing GABAergic inhibitory neurotransmission. Also reduces excitatory synaptic transmission (By similarity). In superior cervical ganglions and cerebral vascular smooth muscle cells; inhibits voltage-gated Ca(2+) channels in a constitutive; as well as agonist-dependent manner (PubMed:17895407). In cerebral vascular smooth muscle cells; cannabinoid-induced inhibition of voltage-gated Ca(2+) channels leads to vasodilation and decreased vascular tone (By similarity). Induces leptin production in adipocytes and reduces LRP2-mediated leptin clearance in the kidney; hence participating in hyperleptinemia. In adipose tissue; CNR1 signaling leads to increased expression of SREBF1; ACACA and FASN genes (By similarity). In the liver; activation by endocannabinoids leads to increased de novo lipogenesis and reduced fatty acid catabolism; associated with increased expression of SREBF1/SREBP-1; GCK; ACACA; ACACB and FASN genes. May also affect de novo cholesterol synthesis and HDL-cholesteryl ether uptake. Peripherally modulates energy metabolism (By similarity). In high carbohydrate diet-induced obesity; may decrease the expression of mitochondrial dihydrolipoyl dehydrogenase/DLD in striated muscles; as well as that of selected glucose/ pyruvate metabolic enzymes; hence affecting energy expenditure through mitochondrial metabolism (By similarity). In response to cannabinoid anandamide; elicits a proinflammatory response in macrophages; which involves NLRP3 inflammasome activation and IL1B and IL18 secretion (By similarity). In macrophages infiltrating pancreatic islets; this process may participate in the progression of type-2 diabetes and associated loss of pancreatic beta-cells (PubMed:23955712).
- Gene Details:
- cannabinoid receptor 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CNR1.
- Isotype:
- IgG
- Molecular Weight:
- 52 kDa
- Protein Details:
- Cannabinoid receptor 1
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
