RFX3 Antibody
Product Sizes
100 ug
£496.00
OAAF04383-100UG
About this Product
- SKU:
- OAAF04383
- Additional Names:
- DNA binding protein RFX3;Regulatory factor X 3;regulatory factor X; 3 (influences HLA class II expression);transcription factor RFX3.
- Clonality:
- Polyclonal
- Extra Details:
- Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1; FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11; DNAH9 and DNAH5) (By similarity). Together with RFX6; participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development; with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (PubMed:20148032). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells (PubMed:12411430).
- Gene Details:
- regulatory factor X3
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human RFX3.
- Molecular Weight:
- 83 kDa
- Protein Details:
- Transcription factor RFX3
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
