SH2D1B Antibody
Product Sizes
100 ug
£496.00
OAAF04278-100UG
About this Product
- SKU:
- OAAF04278
- Additional Names:
- EAT2;EAT-2;EWS/FLI1-activated transcript 2;SH2 domain-containing molecule EAT2;SH2 domain-containing protein 1B.
- Clonality:
- Polyclonal
- Extra Details:
- Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84; SLAMF1; LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through CD244/2B4 without effecting its tyrosine phosphorylation; downstream signaling involves PLCG1 and ERK activation (PubMed:24687958). Activation of SLAMF7-mediated NK cell function does not effect receptor tyrosine phosphorylation but distal signaling (By similarity). In the context of NK cell-mediated cytotoxicity does not enhance conjugate formation with target cells but stimulates polarization of the microtubule-organizing center and cytotoxic granules toward the NK cell synapse (PubMed:24687958). Negatively regulates CD40-induced cytokine production in dendritic cells downstream of SLAM family receptors probably by inducing activation of the PI3K pathway to inhibit p38 MAPK and JNK activation (By similarity).
- Gene Details:
- SH2 domain containing 1B
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human SH2D1B.
- Molecular Weight:
- 15 kDa
- Protein Details:
- SH2 domain-containing protein 1B
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
