PMS2/PMS2CL Antibody
Product Sizes
100 ug
£496.00
OAAF04086-100UG
About this Product
- SKU:
- OAAF04086
- Additional Names:
- DNA mismatch repair protein PMS2;HNPCC4;mismatch repair endonuclease PMS2;MLH4;MMRCS4;PMS1 homolog 2; mismatch repair protein;PMS1 protein homolog 2;PMS2 postmeiotic segregation increased 2;PMS2-C terminal-like protein;PMS2CL;PMSL2;postmeiotic segregation increased 2 nirs variant 6.
- Clonality:
- Polyclonal
- Extra Details:
- Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH6) binding to a dsDNA mismatch; then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III; suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling; a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages.
- Gene Details:
- PMS1 homolog 2; mismatch repair system component
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human PMS2CL.
- Molecular Weight:
- 20 kDa
- Protein Details:
- Mismatch repair endonuclease PMS2|Protein PMS2CL
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
