NPAS4 Antibody
Product Sizes
100 ug
£496.00
OAAF03924-100UG
About this Product
- SKU:
- OAAF03924
- Additional Names:
- bHLHe79;class E basic helix-loop-helix protein 79;HLH-PAS transcription factor NXF;Le-PAS;neuronal PAS domain-containing protein 4;neuronal PAS4;NXF;PAS domain-containing protein 10;PASD10.
- Clonality:
- Polyclonal
- Extra Details:
- Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons; where it induces distinct but overlapping sets of late-response genes in these two types of neurons; allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit; thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons; activates transcription of BDNF; which in turn controls the number of GABA-releasing synapses that form on excitatory neurons; thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons; regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons; probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes; such as short-term and long-term memory; acquisition of experience; fear memory; response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein; such as ARNT; ARNT2 or BMAL1 (PubMed:14701734). Can activate the CME (CNS midline enhancer) element (PubMed:14701734).
- Gene Details:
- neuronal PAS domain protein 4
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human NPAS4.
- Molecular Weight:
- 87 kDa
- Protein Details:
- Neuronal PAS domain-containing protein 4
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
