POLR3C Antibody
Product Sizes
100 ug
£496.00
OAAF03589-100UG
About this Product
- SKU:
- OAAF03589
- Additional Names:
- C82;DNA-directed III 62 kDa polypeptide;DNA-directed RNA polymerase III subunit C;DNA-directed RNA polymerase III subunit RPC3;polymerase (RNA) III (DNA directed) polypeptide C (62kD);polymerase (RNA) III subunit C;RNA polymerase III 62 kDa subunit;RNA polymerase III subunit C3;RPC3;RPC62.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs; such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III; or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts; such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds single-stranded DNA (ssDNA) in a sequence-independent manner (PubMed:21358628).
- Gene Details:
- RNA polymerase III subunit C
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human RPC3.
- Isotype:
- IgG
- Molecular Weight:
- 60 kDa
- Protein Details:
- DNA-directed RNA polymerase III subunit RPC3
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
