CEP152 Antibody
Product Sizes
100 ug
£496.00
OAAF03465-100UG
About this Product
- SKU:
- OAAF03465
- Additional Names:
- asterless;centrosomal protein 152kDa;centrosomal protein of 152 kDa;MCPH4;MCPH9;microcephaly; primary autosomal recessive 4;SCKL5.
- Clonality:
- Polyclonal
- Extra Details:
- Necessary for centrosome duplication; the function seems also to involve CEP63; CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). Acts as a molecular scaffold facilitating the interaction of PLK4 and CENPJ; 2 molecules involved in centriole formation (PubMed:21059844; PubMed:20852615). Proposed to snatch PLK4 away from PLK4:CEP92 complexes in early G1 daughter centriole and to reposition PLK4 at the outer boundary of a newly forming CEP152 ring structure (PubMed:24997597). Also plays a key role in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles (By similarity). Overexpression of CEP152 can drive amplification of centrioles (PubMed:20852615).
- Gene Details:
- centrosomal protein 152
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CEP152.
- Molecular Weight:
- 147 kDa
- Protein Details:
- Centrosomal protein of 152 kDa
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
