MSH2 Antibody
Product Sizes
100 ug
£496.00
OAAF03051-100UG
About this Product
- SKU:
- OAAF03051
- Additional Names:
- COCA1;DNA mismatch repair protein Msh2;DNA mismatch repair protein Msh2 transcript;FCC1;hMSH2;HNPCC;HNPCC1;LCFS2;MMRCS2;mutS homolog 2; colon cancer; nonpolyposis type 1;MutS protein homolog 2.
- Clonality:
- Polyclonal
- Extra Details:
- Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound; heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding; MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer; which is thought to be responsible for directing the downstream MMR events; including strand discrimination; excision; and resynthesis. Recruits DNA helicase MCM9 to chromatin which unwinds the mismatch containg DNA strand (PubMed:26300262). ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange; resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
- Gene Details:
- mutS homolog 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MSH2.
- Molecular Weight:
- 104 kDa
- Protein Details:
- DNA mismatch repair protein Msh2
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
