CCRL1 Antibody
Product Sizes
100 ug
£496.00
OAAF02871-100UG
About this Product
- SKU:
- OAAF02871
- Additional Names:
- atypical chemokine receptor 4;C-C chemokine receptor type 11;CC chemokine receptor-like 1;C-C CKR-11;CCBP2;CC-CKR-11;CCR10;CCR11;CCR-11;CCRL1;CCX CKR;CCX-CKR;chemocentryx chemokine receptor;chemokine (C-C motif) receptor-like 1;chemokine; cc motif; receptor-like protein 1;CKR-11;orphan seven-transmembrane receptor; chemokine related;PPR1;VSHK1.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades; resulting instead in chemokine sequestration; degradation; or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2; CCL8; CCL13; CCL19; CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment; leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9; by reducing the availability of CCL19; CCL21; and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
- Gene Details:
- atypical chemokine receptor 4
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CCRL1.
- Isotype:
- IgG
- Molecular Weight:
- 39 kDa
- Protein Details:
- Atypical chemokine receptor 4
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
