TPX2 Antibody
Product Sizes
100 ug
£496.00
OAAF02746-100UG
About this Product
- SKU:
- OAAF02746
- Additional Names:
- C20orf1;C20orf2;differentially expressed in cancerous and non-cancerous lung cells 2;differentially expressed in lung cells;DIL2;DIL-2;FLS353;GD:C20orf1;HCA519;HCTP4;hepatocellular carcinoma-associated antigen 519;hepatocellular carcinoma-associated antigen 90;p100;preferentially expressed in colorectal cancer;protein fls353;REPP86;restricted expression proliferation associated protein 100;Restricted expression proliferation-associated protein 100;targeting protein for Xklp2;TPX2; microtubule-associated protein homolog;TPX2; microtubule-associated; homolog.
- Clonality:
- Polyclonal
- Extra Details:
- Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142; PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142; PubMed:19208764). TPX2 is inactivated upon binding to importin-alpha (PubMed:26165940). At the onset of mitosis; GOLGA2 interacts with importin-alpha; liberating TPX2 from importin-alpha; allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940).
- Gene Details:
- TPX2 microtubule nucleation factor
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human DIL-2.
- Molecular Weight:
- 85 kDa
- Protein Details:
- Targeting protein for Xklp2
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
