MOB1B Antibody
Product Sizes
100 ug
£496.00
OAAF02516-100UG
About this Product
- SKU:
- OAAF02516
- Additional Names:
- MATS2;MOB kinase activator 1B;mob1 homolog 1A;MOB1 Mps One Binder homolog B;MOB1; Mps One Binder kinase activator-like 1A;mob1A;Mob1B;MOB4A;MOBKL1A;mps one binder kinase activator-like 1A.
- Clonality:
- Polyclonal
- Extra Details:
- Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1; in complex with its regulatory protein SAV1; phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1; which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation; cell death; and cell migration. Stimulates the kinase activity of STK38L.
- Gene Details:
- MOB kinase activator 1B
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MOL1A.
- Molecular Weight:
- 25 kDa
- Protein Details:
- MOB kinase activator 1B
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
