CAMK2B Antibody
Product Sizes
100 ug
£496.00
OAAF02415-100UG
About this Product
- SKU:
- OAAF02415
- Additional Names:
- calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma;calcium/calmodulin-dependent protein kinase type II subunit beta;calcium/calmodulin-dependent protein kinase type II subunit gamma;CaM kinase II beta subunit;CAM2;CAMK;CAMK2;CAMKB;CAMKG;CAMK-II;caMK-II subunit beta;caMK-II subunit gamma;CaMKIIbeta;CaM-kinase II beta chain;MRD54;MRD59;proline rich calmodulin-dependent protein kinase.
- Clonality:
- Polyclonal
- Extra Details:
- Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation; and is involved in dendritic spine and synapse formation; neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons; plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A; which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons; promotes arborization of the dendritic tree and in mature neurons; promotes dendritic remodeling. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles; is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin; a ryanodine receptor-coupling factor; and phospholamban (PLN/PLB); an endogenous inhibitor of SERCA2A/ATP2A2.|Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation; and is involved in sarcoplsamic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles; is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons; may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.
- Gene Details:
- calcium/calmodulin dependent protein kinase II beta|calcium/calmodulin dependent protein kinase II gamma
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CaMK2 beta/gamma.
- Molecular Weight:
- 62 kDa
- Protein Details:
- Calcium/calmodulin-dependent protein kinase type II subunit beta|Calcium/calmodulin-dependent protein kinase type II subunit gamma
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
