AKAP13 Antibody
Product Sizes
100 ug
£496.00
OAAF02387-100UG
About this Product
- SKU:
- OAAF02387
- Additional Names:
- A kinase (PRKA) anchor protein 13;AKAP-13;AKAP-Lbc;A-kinase anchor protein 13;ARHGEF13;breast cancer nuclear receptor-binding auxiliary protein;BRX;c-lbc;guanine nucleotide exchange factor Lbc;HA-3;Ht31;human thyroid-anchoring protein 31;LBC;LBC oncogene;lymphoid blast crisis oncogene;non-oncogenic Rho GTPase-specific GTP exchange factor;p47;PRKA13;protein kinase A-anchoring protein 13;PROTO-LB;PROTO-LBC.
- Clonality:
- Polyclonal
- Extra Details:
- Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812; PubMed:15229649; PubMed:23090968; PubMed:25186459; PubMed:24993829). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases; such as MAPK11 and MAPK14 (PubMed:17537920; PubMed:23716597; PubMed:21224381). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB; leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA); a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:9627117; PubMed:11579095). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1; leading to the activation of downstream MAP kinases; such as MAPK1 or MAPK3 (PubMed:21102438). Functions as scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1; leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42; Ras or Rac (PubMed:11546812). Required for normal embryonic heart development; and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920; PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity).
- Gene Details:
- A-kinase anchoring protein 13
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human AKAP13.
- Molecular Weight:
- 307 kDa
- Protein Details:
- A-kinase anchor protein 13
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
