HCFC1 Antibody
Product Sizes
100 ug
£496.00
OAAF02296-100UG
About this Product
- SKU:
- OAAF02296
- Additional Names:
- C1 factor;CFF;HCF;HCF1;HCF-1;HFC1;host cell factor 1;MRX3;PPP1R89;protein phosphatase 1; regulatory subunit 89;VCAF;VP16 accessory protein;VP16-accessory protein.
- Clonality:
- Polyclonal
- Extra Details:
- Involved in control of the cell cycle (PubMed:10629049; PubMed:10779346; PubMed:15190068; PubMed:16624878; PubMed:23629655). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (PubMed:10675337; PubMed:12244100). Coactivator for EGR2 and GABP2 (PubMed:12244100; PubMed:14532282). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription; respectively) together (PubMed:12670868). Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1 (PubMed:20200153). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Recruits KMT2E/MLL5 to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (PubMed:23629655).
- Gene Details:
- host cell factor C1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human HCFC1.
- Molecular Weight:
- 208 kDa
- Protein Details:
- Host cell factor 1
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
