TOP3B Antibody
Product Sizes
100 ug
£496.00
OAAF02093-100UG
About this Product
- SKU:
- OAAF02093
- Additional Names:
- DNA topoisomerase 3-beta-1;DNA topoisomerase III beta-1;TOP3B1;topoisomerase (DNA) III beta;topoisomerase III beta.
- Clonality:
- Polyclonal
- Extra Details:
- Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme; resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand than undergoes passage around the unbroken strand thus removing DNA supercoils. Finally; in the religation step; the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Possesses negatively supercoiled DNA relaxing activity.
- Gene Details:
- DNA topoisomerase III beta
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human TOP3B.
- Molecular Weight:
- 96 kDa
- Protein Details:
- DNA topoisomerase 3-beta-1
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
