HSPA5 Antibody
Product Sizes
100 ug
£496.00
OAAF01819-100UG
About this Product
- SKU:
- OAAF01819
- Additional Names:
- 78 kDa glucose-regulated protein;binding-immunoglobulin protein;BIP;endoplasmic reticulum chaperone BiP;endoplasmic reticulum lumenal Ca(2+)-binding protein grp78;epididymis secretory sperm binding protein Li 89n;glucose-regulated protein; 78kDa;GRP78;heat shock 70kDa protein 5 (glucose-regulated protein; 78kDa);heat shock protein 70 family protein 5;heat shock protein family A member 5;HEL-S-89n;HSP70 family protein 5;immunoglobulin heavy chain-binding protein.
- Clonality:
- Polyclonal
- Extra Details:
- Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010; PubMed:23769672; PubMed:23990668; PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5; probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958; PubMed:19538957). In the unstressed endoplasmic reticulum; recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1; leading to disrupt the dimerization of ERN1/IRE1; thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1; allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity).
- Gene Details:
- heat shock protein family A (Hsp70) member 5
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human GRP78.
- Molecular Weight:
- 72 kDa
- Protein Details:
- Endoplasmic reticulum chaperone BiP
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
