ZFP36L1 Antibody
Product Sizes
100 ug
£496.00
OAAF01195-100UG
About this Product
- SKU:
- OAAF01195
- Additional Names:
- Berg36;BRF1;butyrate response factor 1;cMG1;early response factor Berg36;EGF-response factor 1;ERF1;ERF-1;mRNA decay activator protein ZFP36L1;RNF162B;TIS11B;TPA-induced sequence 11b;ZFP36-like 1;zinc finger protein 36; C3H type-like 1;zinc finger protein 36; C3H1 type-like 1;zinc finger protein; C3H type; 36-like 1.
- Clonality:
- Polyclonal
- Extra Details:
- Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation; and hence provide a mechanism for attenuating protein synthesis (PubMed:12198173; PubMed:15538381; PubMed:15467755; PubMed:17030608; PubMed:19179481; PubMed:20702587; PubMed:24700863; PubMed:25106868; PubMed:25014217; PubMed:26542173). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258). Functions by recruiting the CCR4-NOT deadenylase complex and components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs; and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:15687258; PubMed:18326031; PubMed:25106868). Induces also the degradation of ARE-containing mRNAs even in absence of poly(A) tail (By similarity). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:12198173; PubMed:15538381; PubMed:15467755; PubMed:17030608; PubMed:19179481; PubMed:20702587; PubMed:24700863; PubMed:25106868; PubMed:25014217; PubMed:26542173). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Promotes ARE-mediated mRNA decay of mineralocorticoid receptor NR3C2 mRNA in response to hypertonic stress (PubMed:24700863). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Positively regulates monocyte/macrophage cell differentiation by promoting ARE-mediated mRNA decay of the cyclin-dependent kinase CDK6 mRNA (PubMed:26542173). Promotes degradation of ARE-containing pluripotency-associated mRNAs in embryonic stem cells (ESCs); such as NANOG; through a fibroblast growth factor (FGF)-induced MAPK-dependent signaling pathway; and hence attenuates ESC self-renewal and positively regulates mesendoderm differentiation (By similarity). May play a role in mediating pro-apoptotic effects in malignant B-cells by promoting ARE-mediated mRNA decay of BCL2 mRNA (PubMed:25014217). In association with ZFP36L2 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle; and hence ensuring accurate variable-diversity-joining (VDJ) recombination and functional immune cell formation (By similarity). Together with ZFP36L2 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA (By similarity). Participates in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function; plays a role in the regulation of nuclear mRNA 3'-end processing; modulates mRNA 3'-end maturation efficiency of the DLL4 mRNA through binding with an ARE embedded in a weak noncanonical polyadenylation (poly(A)) signal in endothelial cells (PubMed:21832157). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (PubMed:15967811). Plays a role in vasculogenesis and endocardial development (By similarity). Plays a role in the regulation of keratinocyte proliferation; differentiation and apoptosis (PubMed:27182009). Plays a role in myoblast cell differentiation (By similarity).
- Gene Details:
- ZFP36 ring finger protein like 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human TISB.
- Molecular Weight:
- 36 kda
- Protein Details:
- mRNA decay activator protein ZFP36L1
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
