MARK2 Antibody
Product Sizes
100 ug
£496.00
OAAF01146-100UG
About this Product
- SKU:
- OAAF01146
- Additional Names:
- ELKL motif kinase 1;EMK1;EMK-1;MAP/microtubule affinity-regulating kinase 2;PAR-1;PAR1 homolog;PAR1 homolog b;Par1b;Par-1b;Ser/Thr protein kinase PAR-1B;serine/threonine protein kinase EMK;serine/threonine-protein kinase MARK2;testicular tissue protein Li 117.
- Clonality:
- Polyclonal
- Extra Details:
- Serine/threonine-protein kinase (PubMed:23666762). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2; DCX; HDAC7; KIF13B; MAP2; MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:23666762). Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2; MAP4 and MAPT/TAU at KXGS motifs; causing detachment from microtubules; and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics; possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B; promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7; promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway; probably by mediating phosphorylation of dishevelled proteins (DVL1; DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.
- Gene Details:
- microtubule affinity regulating kinase 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human MARK2.
- Molecular Weight:
- 87 kDa
- Protein Details:
- Serine/threonine-protein kinase MARK2
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
