IL6ST Antibody
Product Sizes
100 ug
£496.00
OAAF00983-100UG
About this Product
- SKU:
- OAAF00983
- Additional Names:
- CD130;CD130 antigen;CDW130;GP130;gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form;gp130; oncostatin M receptor;HIES4;IL-6 receptor subunit beta;IL-6R subunit beta;IL-6RB;interleukin receptor beta chain;interleukin-6 receptor subunit beta;interleukin-6 signal transducer;membrane glycoprotein 130;membrane glycoprotein gp130;oncostatin-M receptor subunit alpha;sGP130.
- Clonality:
- Polyclonal
- Extra Details:
- Signal-transducing molecule. The receptor systems for IL6; LIF; OSM; CNTF; IL11; CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex; which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009; PubMed:23294003). Mediates signals which regulate immune response; hematopoiesis; pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
- Gene Details:
- interleukin 6 cytokine family signal transducer
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CD130/gp130.
- Molecular Weight:
- 103 kDa
- Protein Details:
- Interleukin-6 receptor subunit beta
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
