Pin1 Antibody
Product Sizes
100 ug
£496.00
OAAF00905-100UG
About this Product
- SKU:
- OAAF00905
- Additional Names:
- DOD;peptidyl-prolyl cis-trans isomerase NIMA-interacting 1;Peptidyl-prolyl cis-trans isomerase Pin1;PPIase Pin1;protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1;protein interacting with never in mitosis A1;rotamase Pin1;UBL5.
- Clonality:
- Polyclonal
- Extra Details:
- Peptidyl-prolyl cis/trans isomerase (PPIase) that binds to and isomerizes specific phosphorylated Ser/Thr-Pro (pSer/Thr-Pro) motifs. By inducing conformational changes in a subset of phosphorylated proteins; acts as a molecular switch in multiple cellular processes (PubMed:21497122; PubMed:22033920; Ref. 21). Displays a preference for acidic residues located N-terminally to the proline bond to be isomerized. Regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Down-regulates kinase activity of BTK (PubMed:16644721). Can transactivate multiple oncogenes and induce centrosome amplification; chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation (PubMed:15664191). Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner (PubMed:17828269). Acts as a regulator of JNK cascade by binding to phosphorylated FBXW7; disrupting FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation: degradation of FBXW7 leads to subsequent stabilization of JUN (PubMed:22608923). May facilitate the ubiquitination and proteasomal degradation of RBBP8/CtIP through CUL3/KLHL15 E3 ubiquitin-protein ligase complex; hence favors DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free; RBBP8-mediated homologous recombination (HR) (PubMed:23623683; PubMed:27561354).
- Gene Details:
- peptidylprolyl cis/trans isomerase; NIMA-interacting 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Pin1.
- Molecular Weight:
- 18 kDa
- Protein Details:
- Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
