ALK Antibody
Product Sizes
100 ug
£496.00
OAAF00866-100UG
About this Product
- SKU:
- OAAF00866
- Additional Names:
- ALK tyrosine kinase receptor;Anaplastic lymphoma kinase;anaplastic lymphoma receptor tyrosine kinase;CD246;CD246 antigen;mutant anaplastic lymphoma kinase;NBLST3.
- Clonality:
- Polyclonal
- Extra Details:
- Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface; through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand; ALK induces tyrosine phosphorylation of CBL; FRS2; IRS1 and SHC1; as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN); a secreted growth factor; and midkine (MDK); a PTN-related factor; thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation; which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1); activates mitogen-activated protein kinases (MAPKs) and PI3-kinase; resulting also in cell proliferation induction. Drives NF-kappa-B activation; probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.
- Gene Details:
- ALK receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human ALK.
- Molecular Weight:
- 176 kDa
- Protein Details:
- ALK tyrosine kinase receptor
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
