ARHGAP35 Antibody
Product Sizes
100 ug
£496.00
OAAF00738-100UG
About this Product
- SKU:
- OAAF00738
- Additional Names:
- glucocorticoid receptor DNA-binding factor 1;glucocorticoid receptor repression factor 1;GRF-1;GRLF1;P190A;P190-A;p190ARhoGAP;p190RhoGAP;rho GAP p190A;rho GTPase-activating protein 35.
- Clonality:
- Polyclonal
- Extra Details:
- Rho GTPase-activating protein (GAP) (PubMed:19673492; PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration; plays an important role in retinal tissue morphogenesis; neural tube fusion; midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus; acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules; such as laminin; to promote neurite outgrowth. Regulates axon outgrowth; guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization; organization and assembly; is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development; is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621).
- Gene Details:
- Rho GTPase activating protein 35
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human GRF-1.
- Molecular Weight:
- 172 kDa
- Protein Details:
- Rho GTPase-activating protein 35
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
