RBBP8 Antibody
Product Sizes
100 ug
£496.00
OAAF00723-100UG
About this Product
- SKU:
- OAAF00723
- Additional Names:
- COM1;CTBP-interacting protein;CTIP;DNA endonuclease RBBP8;JWDS;RBBP-8;retinoblastoma binding protein 8;Retinoblastoma-binding protein 8;Retinoblastoma-interacting protein and myosin-like;RIM;SAE2;SCKL2;sporulation in the absence of SPO11 protein 2 homolog.
- Clonality:
- Polyclonal
- Extra Details:
- Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in DNA-end resection; the first step of double-strand break (DSB) repair through the homologous recombination (HR) pathway. HR is restricted to S and G2 phases of the cell cycle and preferentially repairs DSBs resulting from replication fork collapse. Key determinant of DSB repair pathway choice; as it commits cells to HR by preventing classical non-homologous end-joining (NHEJ). Functions downstream of the MRN complex and ATM; promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage (PubMed:10764811; PubMed:10910365; PubMed:15485915; PubMed:16581787; PubMed:16818604; PubMed:17965729; PubMed:19202191; PubMed:19759395; PubMed:20064462; PubMed:20829486). During immunoglobulin heavy chain class-switch recombination; promotes microhomology-mediated alternative end joining (A-NHEJ) and plays an essential role in chromosomal translocations (By similarity).
- Gene Details:
- RB binding protein 8; endonuclease
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CTIP.
- Molecular Weight:
- 101 kDa
- Protein Details:
- DNA endonuclease RBBP8
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
