ATR Antibody
Product Sizes
100 ug
£496.00
OAAF00519-100UG
About this Product
- SKU:
- OAAF00519
- Additional Names:
- ataxia telangiectasia and Rad3-related protein;FCTCS;FRAP-related protein 1;FRAP-related protein-1;FRP1;MEC1;MEC1; mitosis entry checkpoint 1; homolog;SCKL;SCKL1;serine/threonine-protein kinase ATR.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR); ultraviolet light (UV); or DNA replication stalling; thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1; CHEK1; MCM2; RAD17; RPA2; SMC1 and p53/TP53; which collectively inhibit DNA replication and mitosis and promote DNA repair; recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage; thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.
- Gene Details:
- ATR serine/threonine kinase
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human ATR around the phosphorylation site of Ser428.
- Isotype:
- IgG
- Molecular Weight:
- 301 kDa
- Protein Details:
- Serine/threonine-protein kinase ATR
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
