NTRK2 Antibody
Product Sizes
100 ug
£496.00
OAAF00484-100UG
About this Product
- SKU:
- OAAF00484
- Additional Names:
- BDNF/NT-3 growth factors receptor;BDNF-tropomyosine receptor kinase B;DEE58;EIEE58;GP145-TrkB;neurotrophic tyrosine kinase receptor type 2;OBHD;trk-B;TRKB;TrkB tyrosine kinase;tropomyosin-related kinase B;tyrosine kinase receptor B.
- Clonality:
- Polyclonal
- Extra Details:
- Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival; proliferation; migration; differentiation; and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding; undergoes homodimerization; autophosphorylation and activation. Recruits; phosphorylates and/or activates several downstream effectors including SHC1; FRS2; SH2B1; SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1; FRS2; SH2B1; SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby; plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence; it is able to suppress anoikis; the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
- Gene Details:
- neurotrophic receptor tyrosine kinase 2
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human Trk B around the phosphorylation site of Tyr706 and Tyr707.
- Molecular Weight:
- 91 kDa
- Protein Details:
- BDNF/NT-3 growth factors receptor
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
