FLT3 Antibody
Product Sizes
100 ug
£496.00
OAAF00442-100UG
About this Product
- SKU:
- OAAF00442
- Additional Names:
- CD135;CD135 antigen;fetal liver kinase 2;Fetal liver kinase-2;FL cytokine receptor;FLK2;FLK-2;fms related tyrosine kinase 3;fms-like tyrosine kinase 3;growth factor receptor tyrosine kinase type III;receptor-type tyrosine-protein kinase FLT3;stem cell tyrosine kinase 1;STK1.
- Clonality:
- Polyclonal
- Extra Details:
- Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation; proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1; and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases; including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES; FER; PTPN6/SHP; PTPN11/SHP-2; PLCG1; and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
- Gene Details:
- fms related receptor tyrosine kinase 3
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human FLT3 around the phosphorylation site of Tyr969.
- Molecular Weight:
- 112 kDa
- Protein Details:
- Receptor-type tyrosine-protein kinase FLT3
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
