BLK Antibody
Product Sizes
100 ug
£496.00
OAAF00434-100UG
About this Product
- SKU:
- OAAF00434
- Additional Names:
- b lymphocyte kinase;B lymphoid tyrosine kinase;BLK nonreceptor tyrosine kinase;MODY11;p55-Blk;tyrosine-protein kinase Blk.
- Clonality:
- Polyclonal
- Extra Details:
- Non-receptor tyrosine kinase involved in B-lymphocyte development; differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases; and associated coreceptors. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition; as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199'; as well as CD79B at 'Tyr-196' and 'Tyr-207'. Phosphorylates also the immunoglobulin G receptors FCGR2A; FCGR2B and FCGR2C. With FYN and LYN; plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation. Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation. In pancreatic islets; acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
- Gene Details:
- BLK proto-oncogene; Src family tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human BLK around the phosphorylation site of Tyr501.
- Molecular Weight:
- 57 kDa
- Protein Details:
- Tyrosine-protein kinase Blk
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
