AXL Antibody
Product Sizes
100 ug
£496.00
OAAF00433-100UG
About this Product
- SKU:
- OAAF00433
- Additional Names:
- ARK;AXL oncogene;AXL transforming sequence/gene;JTK11;Tyro7;tyrosine-protein kinase receptor UFO;UFO.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival; cell proliferation; migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand; ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1; PIK3R2 and PIK3R3; but also GRB2; PLCG1; LCK and PTPN11. Other downstream substrate candidates for AXL are CBL; NCK2; SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis; optimal cytokine signaling during human natural killer cell development; hepatic regeneration; gonadotropin-releasing hormone neuron survival and migration; platelet activation; or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response.
- Gene Details:
- AXL receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human AXL around the phosphorylation site of Tyr691.
- Isotype:
- IgG
- Molecular Weight:
- 97 kDa
- Protein Details:
- Tyrosine-protein kinase receptor UFO
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
