HSF1 Antibody
Product Sizes
100 ug
£496.00
OAAF00334-100UG
About this Product
- SKU:
- OAAF00334
- Additional Names:
- heat shock factor protein 1;Heat shock transcription factor 1;HSTF1.
- Clonality:
- Polyclonal
- Extra Details:
- Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR); leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage (PubMed:1871105; PubMed:11447121; PubMed:1986252; PubMed:7760831; PubMed:7623826; PubMed:8946918; PubMed:8940068; PubMed:9341107; PubMed:9121459; PubMed:9727490; PubMed:9499401; PubMed:9535852; PubMed:12659875; PubMed:12917326; PubMed:15016915; PubMed:25963659; PubMed:26754925). In unstressed cells; is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:9727490; PubMed:11583998; PubMed:16278218). Upon exposure to heat and other stress stimuli; undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:1871105; PubMed:1986252; PubMed:8455624; PubMed:7935471; PubMed:7623826; PubMed:8940068; PubMed:9727490; PubMed:9499401; PubMed:10359787; PubMed:11583998; PubMed:12659875; PubMed:16278218; PubMed:25963659; PubMed:26754925). Activation is reversible; and during the attenuation and recovery phase period of the HSR; returns to its unactivated form (PubMed:11583998; PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252; PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925).
- Gene Details:
- heat shock transcription factor 1
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human HSF1 around the phosphorylation site of Ser303.
- Molecular Weight:
- 57 kDa
- Protein Details:
- Heat shock factor protein 1
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
