MST1R Antibody
Product Sizes
100 ug
£496.00
OAAF00172-100UG
About this Product
- SKU:
- OAAF00172
- Additional Names:
- CD136;CDw136;c-met-related tyrosine kinase;macrophage-stimulating protein receptor;MSP receptor;NPCA3;p185-Ron;Protein-tyrosine kinase 8;PTK8;PTK8 protein tyrosine kinase 8;RON;S13 avian erythroblastosis oncogene homolog;S13 erythroblastosis oncogene homolog;SEA.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival; migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand; interacts with the PI3-kinase subunit PIK3R1; PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK; PI3 kinase-AKT; or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration; proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively; RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
- Gene Details:
- macrophage stimulating 1 receptor
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human CD136/RON around the phosphorylation site of Ser1394.
- Isotype:
- IgG
- Molecular Weight:
- 152 kDa
- Protein Details:
- Macrophage-stimulating protein receptor
- Purification:
- The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
