APC Antibody
Product Sizes
100 ug
£496.00
OAAF00159-100UG
About this Product
- SKU:
- OAAF00159
- Additional Names:
- adenomatosis polyposis coli tumor suppressor;adenomatous polyposis coli (APC);adenomatous polyposis coli protein;APC; WNT signaling pathway regulator;BTPS2;deleted in polyposis 2.5;DESMD;DP2;DP2.5;DP3;epididymis secretory sperm binding protein;GS;PPP1R46;protein phosphatase 1; regulatory subunit 46;truncated adenomatosis polyposis coli;WNT signaling pathway regulator.
- Clonality:
- Polyclonal
- Extra Details:
- Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
- Gene Details:
- APC regulator of WNT signaling pathway
- Host:
- Rabbit
- Immunogen:
- The antiserum was produced against synthesized peptide derived from human APC around the phosphorylation site of Ser2054.
- Molecular Weight:
- 311 kDa
- Protein Details:
- Adenomatous polyposis coli protein
- Purification:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
