EPCAM Antibody
Product Sizes
0.1ml
£522.00
OAAD00361-0.1ML
About this Product
- SKU:
- OAAD00361
- Additional Names:
- ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
- Clonality:
- Monoclonal
- Extra Details:
- This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.Tissue specificity: This protein is expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinomas.ABCAM:Epithelial Cell Adhesion Molecule (EpCAM) is a 40 kDa cell surface antigen. This antigen has been identified independently by a number of groups; and has been known by a variety of names. Several monoclonal antibodies have been raised against EpCAM; many of which have been described as tumour specific molecules on carcinomas. EpCAM is a Type 1 transmembrane glycoprotein. It is expressed on the basolateral membrane of cells by the majority of epithelial tissues; with the exception of adult squamous epithelium and some specific epithelial cell types including hepatocytes and gastric epithelial cells.
EpCAM expression has been reported to be a possible marker of early malignancy; with expression being increased in tumour cells; and de novo expression being seen in dysplastic squamous epithelium.BIOLEGEND:This cell surface; glycosyl;ated 40kD protein is highly expressed in the bone marrow; colon; lung; and most normal epithelial cells and is expressed on carcinomas of gastrointestinal origin. - Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of human EPCAM expressed in E. Coli.
- Isotype:
- IgG1
- Molecular Weight:
- 35kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C; for long term storage; store at -20C.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
