P53 Antibody
Product Sizes
0.1ml
£522.00
OAAD00308-0.1ML
About this Product
- SKU:
- OAAD00308
- Additional Names:
- P53; BCC7; LFS1; BMFS5; TRP53
- translate.label.attr.clone:
- 4A8
- Clonality:
- Monoclonal
- Extra Details:
- p53 responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest; apoptosis; senescence; DNA repair; or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines; where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation; DNA-binding; and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion; and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site; and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies; but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms; which can regulate p53 transcriptional activity.
- Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of human p53 expressed in E. Coli.
- Isotype:
- IgG1
- Molecular Weight:
- 43.7kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C; for long term storage; store at -20C.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
