DDR1 Antibody
Product Sizes
0.1ml
£500.00
OAAD00267-0.1ML
About this Product
- SKU:
- OAAD00267
- Additional Names:
- CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A
- translate.label.attr.clone:
- 2G4E12
- Clonality:
- Monoclonal
- Extra Details:
- DDR1: discoidin domain receptor tyrosine kinase 1. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth; differentiation and metabolism. The protein encoded by this gene is a RTK that is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. This protein belongs to a subfamily of tyrosine kinase receptors with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. Its autophosphorylation is achieved by all collagens so far tested (type I to type VI). In situ studies and Northern-blot analysis showed that expression of this encoded protein is restricted to epithelial cells; particularly in the kidney; lung; gastrointestinal tract; and brain. In addition; this protein is significantly over-expressed in several human tumors from breast; ovarian; esophageal; and pediatric brain. This gene is located on chromosome 6p21.3 in proximity to several HLA class I genes. Alternative splicing of this gene results in multiple transcript variants.
- Host:
- Mouse
- Immunogen:
- Purified recombinant fragment of DDR1 (aa602-681) expressed in E. Coli.
- Isotype:
- IgG1
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store at 4C; for long term storage; store at -20C.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
