PEG10 Antibody
Product Sizes
100ul
£615.00
OAAB21592-100UL
About this Product
- SKU:
- OAAB21592
- Additional Names:
- EDR; HB-1; Mar2; RTL2; MEF3L; Mart2; RGAG3; SIRH1
- Clonality:
- Monoclonal
- Extra Details:
- This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames; RF1 and RF2; and expresses two proteins: a shorter; gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer; gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes; this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation; differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies; such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects; indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants; and use of upstream non-AUG (CUG) start codon have been reported for this gene.
- Gene Details:
- paternally expressed 10
- Host:
- Rabbit
- Molecular Weight:
- 80 kDa
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
