BRCC3 Antibody - N-terminal region
Product Sizes
200ul
£597.00
OAAB20949-200UL
About this Product
- SKU:
- OAAB20949
- Additional Names:
- C6.1A; BRCC36; CXorf53
- translate.label.attr.clone:
- RB53911
- Clonality:
- Polyclonal
- Concentration:
- 500 ug/mL
- Extra Details:
- This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC); which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response; where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains; and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya; a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5.
- Gene Details:
- BRCA1/BRCA2-containing complex subunit 3
- Host:
- Rabbit
- Immunogen:
- This BRCC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 18-50 amino acids from human BRCC3.
- Isotype:
- Rabbit Ig
- Molecular Weight:
- 36 kDa
- Purification:
- Protein A column purification; followed by peptide affinity purification
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
