ALK Antibody - C-terminal region
Product Sizes
400ul
£615.00
OAAB20860-400UL
About this Product
- SKU:
- OAAB20860
- Additional Names:
- CD246; NBLST3
- translate.label.attr.clone:
- RB1513-1514
- Clonality:
- Polyclonal
- Concentration:
- 1.43 mg/mL
- Extra Details:
- This gene encodes a receptor tyrosine kinase; which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain; an hydrophobic stretch corresponding to a single pass transmembrane region; and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged; mutated; or amplified in a series of tumours including anaplastic large cell lymphomas; neuroblastoma; and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene; which result in creation of multiple fusion genes in tumourigenesis; including ALK (chromosome 2)/EML4 (chromosome 2); ALK/RANBP2 (chromosome 2); ALK/ATIC (chromosome 2); ALK/TFG (chromosome 3); ALK/NPM1 (chromosome 5); ALK/SQSTM1 (chromosome 5); ALK/KIF5B (chromosome 10); ALK/CLTC (chromosome 17); ALK/TPM4 (chromosome 19); and ALK/MSN (chromosome X).
- Gene Details:
- anaplastic lymphoma receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- This ALK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1591~1620 amino acids from the C-terminal region of human ALK.
- Isotype:
- Rabbit Ig
- Molecular Weight:
- 176 kDa
- Purification:
- SAS precipitation; followed by dialysis against PBS
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
