MSH2 Antibody - middle region
Product Sizes
400ul
£630.00
OAAB17759-400UL
About this Product
- SKU:
- OAAB17759
- Additional Names:
- FCC1; COCA1; HNPCC; LCFS2; hMSH2; HNPCC1; MMRCS2
- Clonality:
- Monoclonal
- Extra Details:
- Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound; heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding; MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer; which is thought to be responsible for directing the downstream MMR events; including strand discrimination; excision; and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange; resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.
- Host:
- Mouse
- Immunogen:
- Purified His-tagged MSH2 protein was used to produced this monoclonal antibody.
- Isotype:
- IgG1
- Molecular Weight:
- 105 kDa
- Purification:
- This antibody is purified through a protein G column; followed by dialysis against PBS.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
