ITGB1 Antibody
Product Sizes
400ul
£630.00
OAAB17758-400UL
About this Product
- SKU:
- OAAB17758
- Additional Names:
- CD29; FNRB; MDF2; VLAB; GPIIA; MSK12; VLA-BETA
- translate.label.attr.clone:
- 1084CT17.4.1
- Clonality:
- Monoclonal
- Extra Details:
- Integrins alpha-1/beta-1; alpha-2/beta-1; alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1; alpha-3/beta-1; alpha-4/beta-1; alpha-5/beta-1; alpha-8/beta-1; alpha-10/beta-1; alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1; alpha-2/beta-1; alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1; cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin; thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform beta-1B interferes with isoform beta-1A resulting in a dominant negative effect on cell adhesion and migration (in vitro). In case of HIV-1 infection; the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. When associated with alpha-7/beta-1 integrin; regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and GNB2L1/RACK1; serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase; required for the successful completion of cytokinesis.
- Host:
- Mouse
- Immunogen:
- Purified His-tagged ITGB1 protein was used to produced this monoclonal antibody.
- Isotype:
- IgG1
- Molecular Weight:
- 88 kDa
- Purification:
- This antibody is purified through a protein G column; followed by dialysis against PBS.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
