ABL1 Antibody - N-terminal region
Product Sizes
400ul
£597.00
OAAB17212-400UL
About this Product
- SKU:
- OAAB17212
- Additional Names:
- ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
- Clonality:
- Polyclonal
- Concentration:
- 0.28 mg/ml
- Extra Details:
- The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation; cell division; cell adhesion; and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain; and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation; suggesting a cell cycle function for ABL1.
- Host:
- Rabbit
- Immunogen:
- This ABL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-260 amino acids from the N-terminal region of human ABL1.
- Isotype:
- IgG
- Molecular Weight:
- 123 kDa
- Protein Details:
- Tyrosine-protein kinase ABL1
- Purification:
- This antibody is purified through a protein A column; followed by peptide affinity purification.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
