ACE2 Antibody - N-terminal region
Product Sizes
400ul
£597.00
OAAB16460-400UL
About this Product
- SKU:
- OAAB16460
- Additional Names:
- ACEH
- Clonality:
- Polyclonal
- Concentration:
- Approximately 0.5mg/ml. Actual concentration varies with each lot.
- Extra Details:
- ACE2 cDNA encodes a deduced 805-amino acid protein containing a potential 17-amino acid N-terminal signal peptide and a putative 22-amino acid C-terminal membrane anchor. It also possesses a zinc metalloprotease consensus sequence and a conserved glutamine residue that may function as a third zinc ligand. ACE2 is expressed predominantly in vascular endothelial cells of the heart and kidney. ACE converts angiotensin I to angiotensin II; ACE2 converts angiotensin I to angiotensin 1-9; which has 9 amino acids. Angiotensin II is a potent blood vessel constrictor; while angiotensin 1-9 does not impact blood vessels but is cleaved by ACE to a shorter peptide; angiotensin 1-7; which is a blood vessel dilator. Spike (S) proteins of coronaviruses; including the SARS coronavirus; bind with cellular receptors to mediate infection of target cells. ACE2 binds the S1 domain of the SARS coronavirus S protein. SARS coronavirus replicates efficiently on ACE2-transfected but not mock-transfected 293T cells. Anti-ACE2 but not anti-ACE1 antibody blocks viral replication on Vero E6 cells. It has been proposed that ACE2 is a functional receptor for SARS coronavirus.
- Host:
- Rabbit
- Immunogen:
- This ACE2 (SARS Receptor) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 59-90 amino acids from the N-terminal region of human ACE2 (SARS Receptor).
- Isotype:
- Ig
- Molecular Weight:
- 92463 Da
- Protein Details:
- Angiotensin-converting enzyme 2
- Purification:
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
